We are pleased to announce that the results from the positive 24w NEXUS interim analysis conducted in 2023 have been published in a manuscript entitled "Safety and efficacy of leriglitazone in childhood cerebral adrenoleukodystrophy (NEXUS): an interim analysis of an open-label, phase 2/3 trial” in eClinicalMedicine, part of THE LANCET DiscoveryScience (https://doi.org/10.1016/j.eclinm.2025.103265).

We would like to thank the patients, their families, the Investigators and their research teams at the centres for their dedication to the study to achieve this first publication.