Minoryx is focused on the discovery and development of novel treatments for severe, orphan diseases of the central nervous system (CNS) with high unmet medical need.
- Our ScienceOur leading program is a novel, selective PPAR gamma agonist
We have discovered and developed a novel, selective PPAR gamma agonist, leriglitazone, which is currently in clinical development for multiple orphan CNS disorders. The lead indication for leriglitazone is X-linked Adrenoleukodystrophy, a devastating neurodegenerative disease which exists in two forms: a chronic form, adrenomyeloneuropathy (AMN) and an acute form, cerebral ALD (cALD). Leriglitazone has demonstrated strong preclinical proof-of-concept in relevant animal models of disease and has successfully completed phase 1 clinical trials. Leriglitazone is currently in a pivotal phase 2/3 study in AMN, a phase 2 in cALD and a phase 2 study in Friedreich's Ataxia.
Our Science Our leading program is a novel, selective PPAR gamma agonistWe have discovered and developed a novel, selective PPAR gamma agonist, leriglitazone, which is currently in clinical development for multiple orphan CNS disorders. The lead indication for leriglitazone is X-linked Adrenoleukodystrophy, a devastating neurodegenerative disease which exists in two forms: a chronic form, adrenomyeloneuropathy (AMN) and an acute form, cerebral ALD (cALD). Leriglitazone has demonstrated strong preclinical proof-of-concept in relevant animal models of disease and has successfully completed phase 1 clinical trials. Leriglitazone is currently in a pivotal phase 2/3 study in AMN, a phase 2 in cALD and a phase 2 study in Friedreich's Ataxia.
- NewsSee allMinoryx Therapeutics doses first patient with leriglitazone in registration-enabling cALD NEXUS trialMinoryx Therapeutics receives US FDA fast-track designation for leriglitazone in the treatment of X-ALDMinoryx Therapeutics receives Orphan Drug Designation from the European Commission for leriglitazone in the treatment of Friedreich’s AtaxiaMinoryx Therapeutics receives FDA Orphan Drug Designation for leriglitazone in Friedreich’s AtaxiaMinoryx Therapeutics to participate in upcoming investor conferencesMinoryx Therapeutics completes enrollment in FRAMES phase 2 trial with leriglitazone in Friedreich’s AtaxiaMinoryx Therapeutics announces first patient dosed in the FRAMES phase 2 trial in Friedreich’s AtaxiaMinoryx Therapeutics appoints Didier Le Normand as Group Chief Financial Officer (CFO) and General Manager of its Belgian subsidiaryMinoryx Therapeutics receives approval from Spanish Regulatory Agency to initiate phase 2 study in Friedreich’s AtaxiaMinoryx Therapeutics extends its activities in Belgium